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癌基因RegⅣ的研究进展
作者:徐佳佳1  郭英2  黄培林1 
单位:1. 东南大学基础医学院 病理学与病理生理学系, 江苏 南京 210009;
2. 南京中医药大学 病理学系, 江苏 南京 210046
关键词:癌基因Reg  消化道肿瘤 信号转导通路 综述 
分类号:R730.231.9
出版年·卷·期(页码):2009·28·第一期(66-69)
摘要:
参考文献:

[1] HARTUPEE J C,ZHANG H,BONALDO M F,et al.Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family:Reg Ⅳ[J].Biochim Biophys Acta,2001,1518(3):287-293.
[2] ZENILMAN M E,MAGNUSON T H,SWINSON K,et al.Pancreatic thread protein is mitogenic to pancreatic-derived cells in culture[J].Gastroenterology,1996,110(4):1208-1214.
[3] CAVALLINI G,BOVO P,BIANCHINI E,et al.Lithostathine messenger RNA expression in different types of chronic pancreatitis[J].Mol Cell Biochem,1998,185(1-2):147-152.
[4] OKAMOTO H.Cyclic ADP-ribose-mediated insulin secretion and Reg,regenerating gene[J].J Mol Med,1999,77(1):74-78.
[5] CHIBA T.Is reg gene mutation involved in the development of enterochromaffin-like cell carcinoid tumors?[J].Gastroenterology,1999,116(6):1489-1491.
[6] ZHANG Y W,DING L S,LAI M D.Reg gene family and human diseases[J].World J Gastroenterol,2003,9(12):2635-2641.
[7] ZHANG Y W,LAI M D,GU X M,et al.Reg Ⅳ,a differentially expressed gene in colorectaladenoma[J].Chinese Medical Journal,2003,116(6):918-922.
[8] SEKIKAWA A,FUKUI H,FUJII S,et al.Possible role of Reg I protein in ulcerative colitis and colitic cancer[J].Gut,2005,54(10):1437-1444.
[9] SEKIKAWA A,FUKUI H,FUJII S,et al.RegⅠ protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer[J].Gastroenterology,2005,128(3):642-653.
[10] NANAKIN A,FUKUI H,FUJII S,et al.Expression of the Reg Ⅳ gene in ulcerative colitis[J].Lab Invest,2007,87(3):304-314.
[11] LAWRANCE I C,FIOCCHI C,CHAKRAVARTI S.Ulcerative colitis and Crohn's disease:distinctive gene expression profiles and novel susceptibility candidate genes[J].Hum Mol Genet,2001,10(5):445-456.
[12] DIECKGRAEFE B K,STENSON W F,KORZENIK J R,et al.Analysis of mucosal gene expression in inflammatory bowel disease by parallel oligonucleotide arrays[J].Physiol Genomics,2000,4(1):1-11.
[13] KNIGHT P A,PEMBERTON A D,Robertson K A,et al.Expression profiling reveals novel innate and inflammatory responses in the jejunal epithelial compartment during infection with Trichinella spiralis[J].Infect Immun,2004,72(10):6076-6086.
[14] VIOLETTE S,FESTOR E,PANDREA-VASILE I,et al.Reg Ⅳ,a new member of the regenerating gene family,is overexpressed in colorectal carcinomas[J].Int J Cancer,2003,103(2):185-193.
[15] RECHRECHE H,MONTALTO G,MALLO G V,et al.Pap,reg Ⅰ and reg Ⅰ mRNAs are concomitantly up-regulated during human colorectal carcinogenesis[J].Int J Cancer,1999,81(5):688-694.
[16] BISHNUPURI K S,LUO Q,MURMU N,et al.Reg Ⅳ activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas[J].Gastroenterology,2006,130(1):137-149.
[17] OUE N,KUNIYASU H,NOGUCHI T,et al.Serum concentration of Reg Ⅳ in patients with colorectal cancer:overexpression and high serum levels of Reg Ⅳ are associated with liver metastasis[J].Oncology,2007,72(5-6):371-380.
[18] MITANI Y,OUE N,MATSUMURA S,et al.Reg Ⅳ is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy[J].Oncogene,2007,26(30):4383-4593.
[19] SAWAKI A,TAKAYAMA R,MIZUNO N,et al.A prospective study for serum Reg Ⅳ protein in pancreatic cancer as a tumor marker[J].Gastrointestinal Malignancies,2007,277(6):3559-3564.
[20] GU Z,RUBIN M A,YANG Y,et al.Reg Ⅳ:a promising marker of hormone refractory metastatic prostate cancer[J].Clin Cancer Res,2005,11(6):2237-2243.

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