掺杂F<sub>3</sub>O<sub>4</sub>磁性纳米粒子壳聚糖凝胶的制备及其性质研究-东南大学学报医学版

掺杂F₃O₄磁性纳米粒子壳聚糖凝胶的制备及其性质研究

单位：1. 东南大学生物科学与医学工程学院,生物电子学国家重点实验室,江苏省生物材料与器件重点实验室,江苏南京 210096;
2. 东南大学附属中大医院康复科,江苏南京 210009

分类号：O648.17

出版年·卷·期（页码）：2012·31·第五期（567-571）

摘要：

目的:制备用聚丙烯酸(PAA)包裹的水溶性四氧化三铁(Fe₃O₄)纳米粒子(PAA@Fe₃O₄ NPs)掺杂的壳聚糖水凝胶,并对其进行表征。方法:用戊二醛为交联剂,对壳聚糖进行交联,向其中添加PAA@Fe₃O₄ NPs,获得Fe₃O₄磁性纳米粒子均匀掺杂的水凝胶。应用衰减全反射傅利叶变换红外线光谱(ATR-FTIR)分析仪和流变仪对凝胶的化学结构、流变学性质和溶胀率等进行表征。结果:ATR-FTIR结果显示,戊二醛交联的壳聚糖水凝胶中交联点-C=N-位于1650cm^-1附近。Fe₃O₄磁性纳米粒子均匀掺杂在戊二醛交联的壳聚糖水凝胶中,其存储模量G'远大于损耗模量G″,具有高的溶胀率。结论:Fe₃O₄磁性纳米粒子可以均匀分布在戊二醛交联的壳聚糖水凝胶中,并显示出良好的弹性模量,是一种有潜力的烧伤瘢痕增生抑制辅助用凝胶材料。

Objective: To synthesis a kind of glutaraldehyde crosslinked chitosan hydrogels embedded with magnetic Fe₃O₄ nanoparticles, and characterize it. Methods: Using glutaraldehyde to react with chitosan with the addition of poly(acrylic acid) coated Fe₃O₄ nanoparticles(PAA@Fe₃O₄ NPs) to prepare chitosan hydrogel embedded with Fe₃O₄ nanoparticles. The obtained hydrogel was characterized by ATR-FTIR, rheology and optical microscope. Results: ATR-FTIT measurements indicated the existence of Schiff base-C=N- at 1641-1648cm^-1. Optical microscope displayed the nearly uniform distribution of Fe₃O₄ NPs in hydrogel. The storage modulus G' of hydrogel ranged from 3500 to 6500 Pa and the loss modulus G″ was at about 100-200 Pa. Conclusion: This kind of glutaraldehyde crosslinked chitosan hydrogels embedded with Fe₃O₄ nanoparticles is potential material for burns recovery and reshaping.

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