重型肝炎概念、名称不一,国内亦称重症肝炎,国外称暴发型肝炎,还因原因不同提出急性肝衰竭、暴发性肝衰竭等概念[1],是短期内大量肝细胞坏死或严重变性致肝功能衰竭的一类综合征,主要表现为黄疸、凝血功能障碍等.与慢性肝衰竭不同,重型肝炎无肝硬化病史,亦可无肝性脑病发生[2].该病特点为发展迅速、病情严重、症状复杂、并发症多、病死率高,但潜在可逆转[3].在我国,重型肝炎主要由病毒感染引起,其次为药物性肝炎、自身免疫性肝炎[4].

[1] 周永兴. 重型肝炎的临床分型及诊断标准. 实用肝脏病杂志2004(1). doi:10.3969/j.issn.1672-5069.2004.01.001
[2] 王宇明, 陈耀凯. 肝衰竭/重型肝炎的研究进展. 临床内科杂志2002(4). doi:10.3969/j.issn.1001-9057.2002.04.003
[3] BERNUAU J. Acute liver failure:avoidance of deleterious cofactors and early specific medical therapy for the liver are better than late intensive care for the brain. 2004. doi:10.1016/j.jhep.2004.05.007
[4] 李小毛. 妊娠合并重型肝炎的治疗现状及进展. 新医学2005(2). doi:10.3969/j.issn.0253-9802.2005.02.002
[5] 刘丝荪, 易为民. 妊娠期肝功能衰竭的抢救. 中国实用妇科与产科杂2001(6). doi:10.3969/j.issn.1005-2216.2001.06.010
[6] JAISWAL S P, JAIN A K, NAIK G. Viral hepatitis in pregnancy. 2001. doi:10.1016/S0020-7292(0)00264-2
[7] 曹泽毅. 中华妇产科学, 1999
[8] 中华医学会传染病与寄生虫分会肝病学分会, 中华医学会肝病学分会. 病毒性肝炎防治方案. 中华肝脏病杂志2000(6)
[9] 王德智. 妊娠合并重症肝炎的诊断和治疗. 中国实用妇科与产科杂志2001(6). doi:10.3969/j.issn.1005-2216.2001.06.003
[10] VCEA A. Treatment of the side effects of antiviral therapy, 2005(5)
[11] ANDREONE P, CURSARO C, GRAMENZI A. In vitro effect of thymosin-alphal and inter-feron-alphaon Th1 and Th2 cytokinesyn thesisnpatients with chronic hepatitis C, 2001(8)
[12] STRAIN A J, NEUBERGER J M. A bioartificial liver-state of the art. 2002(5557). doi:10.1126/science.1068660
[13] HUSSAINI S H, SKIDMORE S J, RICHARDSON P. Severe hepatitis E infection during pregnancy. 1997(4). doi:10.1046/j.1365-2893.1997.00123.x
[14] SHANLEY C J, BRAUN D K, BROWN K. Fulminant hepatic failure secondary to herpes simplex virus hepatitis. 1995(1). doi:10.1097/00007890-199501150-00028
[15] BERNAL W, WENDON J. Liver transplantation in adults with acute liver failure. 2004. doi:10.1016/j.jhep.2003.11.020
[16] BAUER M, PAXIAN M, KORTGEN A. Acute liver failure.Current aspects of diagnosis and therapy, 2004(6)
[17] 谢青, 桂红莲. 肝衰竭的诊断和治疗. 世界感染杂志2006(1)
[18] TANK P D, NADANWAR Y S, MAYADEO N M. Outcome of pregnancy with severe liver disease. 2002(1). doi:10.1016/S0020-7292(1)00562-8
[19] ONG J P, AGGARWAL A, KRIEGER D. Correlation between ammonia levels and the severity of hepatic encephalopathy. 2003
[20] ELLIS A J, WENDON J, WILLIAMS R. Subclinical seizure activity and prophylactic phenytoin infusion in acute liver failure:a controlled trial. 2000. doi:10.1053/jhep.2000.9775
[21] BHATIA V, BATRA Y, ACHARYA S K. Prophylactic phenytoin does not improve cerebral edema or survival in acute liver failure:a controlled clinical trial. 2004(1). doi:10.1016/j.jhep.2004.03.017
[22] RIORDAN S M, WILLIAMS R. Mechanism of hepatocyte injury,multiorgan failure,and prognostic criteria in acute liver failure. 2003. doi:10.1055/s-2003-42639
[23] YANG Y B, LI X M, SHI Z J. Pregnant woman with fulminant hepatic failure caused by hepatitis B virus infection:a case report. 2004(15)
[24] SATO T, HASHIGUCHI A, MITSUSE T. Anesthesia for cesarean delivery in a pregnant woman with acute hepatic failure, 2000
[25] LI X M, MA L, YANG Y B. Clinical characteristics of fulminant hepatitis in pregnancy. 2005(29)