吡柔比星膀胱内灌注防治浅表性膀胱癌术后复发(附109例报告)-东南大学学报医学版

吡柔比星膀胱内灌注防治浅表性膀胱癌术后复发(附109例报告)

单位：东南大学医学院附属徐州医院,泌尿外科,江苏,徐州,221009

分类号：R737.14, R730.53

出版年·卷·期（页码）：2006·25·第二期（113-115）

摘要：

目的:评价吡柔比星膀胱灌注防治膀胱癌术后复发的效果.方法:选择109例膀胱肿瘤患者,给予吡柔比星30 mg溶于50 ml葡萄糖中行膀胱内灌注,每次保留40～60 min,每3～6个月膀胱镜检查1次,术后随访.结果: 109例患者随访15～30个月,平均17.5个月,复发11例,复发率10.1%.结论:吡柔比星膀胱灌注对防治浅表性膀胱癌术后复发效果满意,副作用少.

Objective To evaluate effectiveness of instilling pirarubicin(THP) intrvesically after operation of bladder carcinoma to prevent tumor recurrence.Methods 109 patients with superficial bladder carcinoma were instilled intravesically with 30?mg THP added in 50?ml glucose for 40 to 60 minutes in the bladder.Cystoscopy was carried out 3 to 6 months afterwards and all patients had been followed up.Result All patients had been followed up for 15 to 30 months(mean 17.5 months),11 cases had tumor recurrence,the tumor recurrence rate was 10.1%(11/109).Conclusion Intravesical instillation of THP effectively prevents superficial bladder carcinoma from postoperative recurrence with mild side effects.

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