Objective To study the expression of collagen Ⅳ protein and the clinical significance in mucinous carcinomas(MC) of breast, stomach and large intestine. Methods 120 cases of carcinomas were examined with S?P immunohistochemistry.Results The expression of collagen Ⅳ had significantly differences in non?mucinous and mucinous carcinomas of breast, stomach and large intestine. Compared with the stomach and large intestine, mucinous carcinoma of the breast showed a high expression of Ⅳ(70%). In addition, there was a significant difference in the expression of collagen Ⅳ between metastatic MC and non?metastatic MC.Conclusion The higher expression of collagen Ⅳ in mucinous carcinomas of breast is related to its poorly metastatic activity. |