Objective  In order to evaluate whether clinical diagnosis is consistent with pathological diagnosis in 《prevention and treatment to virus hepatitis(probation)》.Methods  According to the pathological diagnosis of 51 patients died of virus hepatitis,some sorts of biochemical indices in clinical diagnosis were analysed contrastly.Result  In these biochemical indies  of dying patients,the prothrombin activity(PTA) was the most valubale in diagnosis;total bilimbin(TBil) and alanine trasaminas(ALT) were the second;albumin,albumin  globulin ratio and   γ    globulin were the least useful.Using prothrombin activity less than 40% as the essential condition in the diagnosis of severe virus hepatitis, it matched acute and subacute virus hepatitis very well.25%(5/20) chronic severe virus hepatitis were missed diagnosis and 33.5%(7/21) no  severe virus hepatitis were mistaked for chronic severe hepatitis according to this standard.Conclusion  The biochemical indices of severe virus hepatitis should be studied and revised.