Objective  Hyaluronic acid was synthesized in laboratory by solution fermentation.Method  Streptococcus strain from being selected and multiplied was cultured.In this method,natural nitrogen sources in ordinary fermentation were substituted by inorganic synthesized nitrogen sources.The pH,temperature,and aeration condition of the solution was strictly controlled in the fermentation.The final fermented solution was treated by chemical method.Result  The mean productivity was 1.5?g·L    -1  .Conclusion  The purity of the product obtained in this article was higher than that obtained in ordinary fermentation.The product could be used as cosmetic substrate without further purification.The cost for raw materials and extractions was lower in this method than that in ordinary fermentation method.