奥兰扎平治疗精神分裂症58例临床观察-东南大学学报医学版

奥兰扎平治疗精神分裂症58例临床观察

单位：南京医科大学,附属脑科医院,江苏,南京,210029

分类号：R749.3

出版年·卷·期（页码）：2002·21·第四期（324-325）

摘要：

目的:观察奥兰扎平治疗精神分裂症的临床疗效与安全性.方法:选择58例精神分裂症病人,开始给予奥兰扎平5mg*d-1,3d后根据临床疗效、副反应情况酌情增加剂量,最大剂量不超过20mg*d-1,治疗8周.治疗前及治疗后每2周用PANSS、CGI、TESS量表评定1次.结果:治疗后PANSS总分、各因子分较治疗前显著下降(P<0.01),副反应主要有抗胆碱症状、过度镇静、体重增加、一过性丙氨酸氨基转移酶升高.结论:奥兰扎平是一种安全、有效、副作用较轻的抗精神病药.

Objective To explore the effect and safety of olanzapine.Methods 58 in-patients diagnosed as schizophrenia according to CCMD2R had been given olanzapine at least for 8 weeks.The dosage was 5mg·d -1 at the beginning.Afterwards,the dosage was adjusted according to clinical effect and side effect,and the maximum dosage was no more than 20mg·d -1.PANSS,CGI and TESS were evaluated before treatment and every other 2 weeks after treatment.Result PANSS total score and all factors score were significantly lower (P<0.01) in the end of treatment than in the beginning.The side effects were mainly antimuscarinic activity,somnolence,weight gain,transitory and reversible ALT increasing.Conclusion Olanzapine is one of the effective and safe antipsychotics.

参考文献：

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