Objective To investigate clinical significances of detecting serum procalcitonin(PCT) in various infectious disease,explore the relationship between PCT and infection.Methods Serum PCT were measured by semi-quantitative solid-phase immunoassay in 356 patients with different kinds of infectious diseases,and then were categorized into four groups: PCT<0.5?μg·L -1,0.5?μg·L -1≤PCT<2.0?μg·L -1,2.0?μg·L -1≤PCT<10.0?μg·L -1 and PCT≥10.0?μg·L -1.The relationship between serum levels of procalcitonin and viral infection or bacterial infection was analysed.Results If PCT levels ≥0.5?μg·L -1 was taken as diagnostic standard and systemic infectious reaction syndrome parameters were combined,the test’s sensitivity,specificity,positive predictive value,negative predictive value,positive likelihood ratio,negative likelihood ratio and accuracy ratio in diagnosing bacterial infectious diseases was 98.7%,72.0%,49.4%,99.5%,3.53,0.018 and 77.80%,respectively.Conclusion The study suggests that semi-quantitative detection of serum PCT might help us to identify bacterial infection from non-bacterial infection,and might offer valuable data for choosing antibiotic therapy.On the other hand,PCT levels might reflect the disease severity. |
