Objective To investigate the effect of auxiliary heterotopic partial liver transplantation on acute liver failure.Methods Auxiliary heterotopic partial liver transplantation was performed in two groups of pigs.In group A,recipients’liver remained untouched,while their liver artery was ligated,portal vein narrowed;donated liver was transplanted under the recipients’ right liver,portal vein supply was constructed only.In group B,the same procedure was performed except that both portal vein supply and arterial blood supply were constructed of donated liver.The living condition,liver function,pathology and bile secretion of donated liver were observed and analysed.Results The surviving rates of liver were higher in group B than that in group A significantly.The concentration of bilirubin did not significantly changed after operation in group B,while it dramatically increased in group A after operation,the concentrations of bilirubin in group A was significantly higher than that in group B 2 days after operation.In group B,bile secretion of donated liver was fairly good,hepatocyte of donated survived and proliferated well.In group A,the donated liver didn’t secrete bile,and hepatocyte was necrotic.Conclusion Auxiliary heterotopic partial liver transplantation is effective to treat liver failure,it can be used in clinical to treat acute liver failure or fulminant liver failure. |
