两种隐形眼镜对护理液中薄荷醇的吸收及释放研究-东南大学学报医学版

两种隐形眼镜对护理液中薄荷醇的吸收及释放研究

单位：1. 东南大学公共卫生学院,江苏南京 210009;
2. 海昌隐形眼镜有限公司,江苏丹阳 212331

分类号：TS959.62;R16

出版年·卷·期（页码）：2014·33·第二期（143-146）

摘要：

目的：检测两种隐形眼镜片对护理液中薄荷醇的吸收和释放程度。方法：样品经C18键和硅胶固相萃取后，采用毛细管气相色谱柱法分离和FID检测器检测。结果：J1102809和G1105599隐形眼镜单位质量（mg）干镜片吸收和释放薄荷醇分别为0.118 2、0.120 5 μg和0.004 3、0.005 6 μg。结论：隐形眼镜片对护理液中薄荷醇的吸收和释放均为微量，可安全使用。

Objective: In functional care solution, the menthol absorption and release of contact lenses was studied. Methods: The sample was concentrated by C18 column solid-phase extraction, and analyzed by capillary gas chromatography and FID detector. Results: The menthol absorption and release of per unit weight (mg) J1102809 and G1105599 contact lenses were 0.118 2 μg、0.120 5 μg,and 0.004 3 μg、0.005 6 μg, respectively. Conclusion: The results show that menthol in functional care solution might be safe for use taking the trace quantity of menthol into account.

参考文献：

[1] 胡士高,俞佳,宁黎丽,等.眼用制剂中添加清凉剂的思考[J].中国现代应用药学,2010,27(1):38-39.
[2] 程阔菊,王晖,陈垦.薄荷醇的安全性研究[J].辽宁中医杂志,2010,37(2):377-380.
[3] 齐红艺,李莉,吴纯洁.薄荷醇促渗透作用的研究进展[J].时珍国医国药,2006,17(9):1176-1178.
[4] ISO10344:1996《光学和光学仪器接触镜测试用盐溶液》[S].

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