Cav-1在胰腺癌中表达及与临床预后关系的研究-东南大学学报医学版

Cav-1在胰腺癌中表达及与临床预后关系的研究

单位：西安交通大学医学院第二附属医院普通外科, 陕西西安 710004

分类号：R735.9

出版年·卷·期（页码）：2015·34·第四期（552-557）

摘要：

目的:肿瘤的发生发展不仅与肿瘤细胞的增殖有关,还依赖于肿瘤细胞和间质微环境之间的相互作用,对肿瘤微环境起关键调节作用的间质小窝蛋白-1(Cav-1)可能是一个潜在的治疗靶点,本研究旨在探讨胰腺癌间质Cav-1的表达能否作为客观的预后标志物。方法:选取45例胰腺癌标本,应用免疫组化法测定胰腺癌、癌旁及正常组织间质Cav-1表达,分析间质Cav-1的表达与临床病理特征和预后的相关性。结果:6例(13.3%)标本间质Cav-1呈强染色,8例(17.8%)呈低-中度染色,31例(68.9%)无染色。间质Cav-1表达缺失与TNM分期(P=0.018)、淋巴结转移(P=0.014)、远处转移(P=0.027)相关,与年龄、性别、组织学分级和肿瘤大小无显著性相关(P>0.05)。结论:胰腺癌间质Cav-1是独立预后指标,可作为胰腺癌有效治疗的靶标。

Objective: Cancer development and progression is not only associated with the tumor cell proliferation but also depends on the interaction between tumor cells and the stromal microenvironment. A new understanding of the role of the tumor microenvironment suggests that the loss of stromal caveolin-1 (Cav-1) as a key regulator may become a potential therapy target. This study aims to elucidate whether stromal Cav-1 expression in pancreatic cancer can be a strong prognosis biomarker. Methods: Tissue samples from 45 pancreatic cancer patients were studied. Stromal Cav-1 expression was measured from pancreatic cancer, paraneoplastic, and normal tissue by using immunohistochemistry. We analyzed the correlation of stromal Cav-1 expression with clinicopathologic features and prognostic. Results: Specimens from six patients(13.3%) showed high levels of stromal Cav-1 staining, those from eight patients(17.8%) showed a lower, intermediate level of staining, whereas those from 31 patients (68.9%) showed an absence of staining. Stromal Cav-1 loss was associated with TNM stage(P=0.018), lymph node metastasis(P= 0.014), distant metastasis(P= 0.027). The relationships of age, sex, histological grade, and tumor size with stromal Cav-1 expression were not significant(P>0.05). Conclusion: The loss of stromal Cav-1 in pancreatic cancer is an independent prognostic indicator, thus suggesting that stromal Cav-1 may be an effective therapeutic target for patients with pancreatic cancer.

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