非酒精性脂肪性肝病合并早发冠心病患者视黄醇结合蛋白4的检测及其意义-东南大学学报医学版

非酒精性脂肪性肝病合并早发冠心病患者视黄醇结合蛋白4的检测及其意义

单位：1. 东南大学附属第二医院心内科, 江苏南京 210003;
2. 东南大学附属中大医院心内科, 江苏南京 210009

分类号：R575.5

出版年·卷·期（页码）：2015·34·第五期（766-769）

摘要：

目的:观察非酒精性脂肪性肝病(NAFLD)患者血清视黄醇结合蛋白4(RBP4)水平与早发冠心病的相关性。方法:选择79例NAFLD患者,经冠状动脉造影分为早发冠心病组49例和对照组30例。患者再根据肝脏B超检查结果分为轻、中、重度脂肪肝组。所有患者均抽外周静脉血检测生化指标、RBP4和超敏C反应蛋白(hs-CRP)水平,并行组间比较。结果:与对照组比较,早发冠心病组血清RBP4、hs-CRP、LDL-C水平均明显增加,差异有统计学意义(P<0.05)。与轻度脂肪肝组比较,重度脂肪肝组合并冠心病人数增加,中度和重度脂肪肝组RBP4水平增加,差异有统计学意义(P<0.05)。结论:对NAFLD患者,RBP4在合并早发冠心病者中增高,并与脂肪肝的严重程度相关。

Objective: To assess the correlation of retinol-binding protein 4(RBP4) and premature coronary artery disease in patients with non-alcoholic fatty liver diseases(NAFLD).Methods: 79 patients with NAFLD were selected for the study. With the help of coronary angiography, they were divided into two groups: premature coronary artery disease group with 49 patients and control group with 30 patients. Based on results of ultrasound examinations, they were further divided into three groups: mild fatty liver group, moderate fatty liver group and severe fatty liver group. Biochemical indexes, serum levels of RBP4 and C reactive protein were measured for correlation analysis in peripheral venous blood of the 79 patients. Results: Compared to the control group, serum levels of RBP4; C reactive protein,and LDL-C in premature coronary artery disease group had significantly larger increase(P<0.05). The number of patients with coronary artery disease in severe fatty liver group, and serum levels of RBP4 in severe and moderate fatty liver groups increased significantly more than in themild fatty liver group(P<0.05). Conclusion: For NAFLD patients, RBP4, which increases in premature coronary artery, is closely associated with the severity of fatty liver disease.

参考文献：

[1] CAVE M,DEACIUC I,MENDEZ C,et al.Non-alcoholic fatty liver disease:predisposing factors and the role of nutrition[J].J Nutr Biochem,2007,18,184-195.
[2] SEHWIMMER J B,BEHLING C,NEWBURY R,et al.Histopathology of pediatric nonalcoholic fatty liver disease[J].Hepatology,2005,42:641-649.
[3] ACIKEL M,SUNAY S,KOPLAY M,et al.Evaluation of ultrasonographic fatty liver and severity of coronary atherosclerosis,and obesity in patients undergoing coronary angiography[J].Anadolu Kardiyol Derg,2009,9:273-279.
[4] GIBY V G,AJITH T A.Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease[J].World J Hepatol,2014,6(8):570-579.
[5] BREA A,MOSQUERA D,MARTIN E,et al.Nonalcoholic fatty liver disease is Associated with carotid atherosclerosis:a case-control study[J].Arterioscler Thtomb Vasc Biol,2005,25:1045-1050.
[6] 柴伟栋,陈家伟,汪承亚,等.胰岛素介导的内皮依赖性血管舒张功能与高血糖关系的实验研究[J].中华内分泌代谢杂志,2002,18:59-62.
[7] QUADRO L,HAMBERGER L,COLANTUONI V,et al.Understanding the physiological role of retinol binding protein in vitamin A metabolism using transgenic and knock out mouse models[J].Mol Aspects Med,2003,24:421-430.
[8] LIN C C,LAI M M,LI T C,et al.Relationship between serum retinol-binding protein 4 and visfatin and the metabolic syndrome [J].Diabetes Res Clin Pract,2009,85(1):124-129.
[9] von EYNATTEN M,LEPPER P M,LIU D,et al.Retinol-binding protein 4 is associated with components of the metabolic syndrome,but not with insulin resistance,in men with type 2 diabetes or coronary artery disease[J].Diabetologia,2007,50(9):1930-1937.
[10] LI F,XIA K,SHEIKH M,et al.Involvement of RBP4 in hyperinsulinism-induced vascular smooth muscle cell proliferation[J].Endocrine,2015,48(2):472-482.
[11] LIU Y,WANG D,LI D,et al.Associations of retinol-binding protein 4 with oxidative stress,inflammatory markers,and metabolic syndrome in a middle-aged and elderly Chinese population[J].Diabetol Metab Syndr,2014,6(1):25.
[12] LAMBADIARI V,KADOGLOU N P,STASINOS V,et al.Serum levels of retinol-binding protein-4 are associated with the presence and severity of coronary artery disease[J].Cardiovasc Diabetol,2014,13(1):121.
[13] 谢芳艺,陈忠,丁震,等.人视黄醇结合蛋白4水平升高与冠心病及其预后相关[J].现代医学,2012,40(6):651-654.
[14] SUH J B,KIM S M,CHO G J,et al.Serum AFBP levels are elevated in patients with nonalcoholic fatty liver disease[J].Scand J Gastroenterol,2014,49(8):979-985.

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