乳腺癌组织缺失基因1（deleted in breast cancer-1，DBC1）作为一种近年来新发现的基因已经被证实参与胃癌等多种肿瘤的形成和发展，但具体机制仍所知甚少。通过沉默交配信息校准2同系物（silent mating type inforation regulation 2 homolog 1，SIRT1）去乙酰化活性的负调控，以及与其他因子如酪氨酸激酶2α（CK2α）、核转录因子κB（NF-κB）、蛋白激酶等的相互作用，DBC1对胃癌的发生、进展以及预后有一定影响。因此，DBC1作为治疗胃癌的新靶点逐渐为人们所重视，使我们对防治胃癌有了进一步的了解和突破。

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