Objective:To investigate the relationship between Y160X site polymorphism of Lp-PLA2 gene and myocardial infarction(MI).Methods:Y160X site polymorphism of Lp-PLA2 gene was tested in case group and control group.Logistic regression analysis was used to analyze relationship between Y160X site polymorphism of Lp-PLA2 gene and MI.Serum Lp-PLA2,lipids,glucose,HsCRP,IL-6,IL-10 of the 2 groups were detected simultaneously.Results:The serum levels of TC,TG,LDL-C,Lp-PLA2,HsCRP,IL-6,and positivie rate of family history in case group were higher than those in control group;while the levels of HDL-C,IL-10 were lower than those in control group (P<0.05).Levels of Lp-PLA2,HsCRP,IL-6 decreased after 1 week,1month,whereas the level of IL-10 increased (P<0.05).Genotype of Lp-PLA2 gene was risk factor of MI.Conclusions:The Y160X(T/A) site polymorphism of LP-PLA2 gene may be one pathogeny of MI. |