Objective:To investigate the correlation between insulin-like growth factor-1 (IGF-1) and insulin resistance (IR) and the role in type 2 diabetes (T2DM) combined with osteoporosis (OP), by determining IGF-1 level in T2DM combined with OP patients' serum. Methods:115 patients with T2DM combined with OP in our hospital from January 2013 to June 2015 were selected and randomly divided into control group (48 cases, non-OP group) and the experimental group of 67 cases (OP group), according to their bone mineral density (BMD) values and the diagnosis standard of osteoporosis. We detected and compared differences in fasting blood glucose (FBG), fasting insulin (FINS), insulin sensitivity index (ISI), insulin resistance index (IRI), IGF-1, and BMD. The correlation analysis between IGF-1 and IR of patients serum in the experimental group was made, and a multifactor related statistical analysis was performed to analyze the related risk factors in T2DM combined with OP. Results:Compared with the control group, the levels of IGF-1[(109.87±22.85)μg·L-1], BMD[(-2.83±0.35)g·cm-2] and ISI(55.94±7.79)in the experimental group were significantly lower, but the levels of FBG[(8.69±0.80)mmol·L-1, FINS[(21.42±1.66)mIU·L-1] and IRI (8.27±1.15) were significantly higher(P<0.0 or P<0.05). The levels of IGF-1 was negatively correlated to FBG, FINS and IRI, but positively correlated to BMD and ISI (P<0.01 or P<0.05). Multiariable logistic regression analysis showed that the level of IGF-1, FBG, FINS and ISI were the related risk factors in T2DM combined with OP (OR=0.958, 4.704, 1.985, 0.812, P<0.01 or P<0.05). Conclusion:The low level of IGF-1, ISI, and the higher level of FBG, FINS are considered as the risk factors of T2DM combined with OP. |
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