降压药物联合高压氧治疗原发性高血压及减少并发症的临床效果分析-东南大学学报医学版

降压药物联合高压氧治疗原发性高血压及减少并发症的临床效果分析

单位：1. 青海省药品采购中心药品科, 青海西宁 810000;
2. 青海省人民医院检验科, 青海西宁 810000

分类号：R544.1

出版年·卷·期（页码）：2017·36·第五期（776-780）

摘要：

目的：探讨降压药物联合高压氧治疗原发性高血压的临床效果及减少并发症的效果。方法：选取本院2014年1月至2015年1月收治的110例原发性高血压疾病患者，采用随机数字表法分为试验组和对照组各55例，试验组采用降压药物联合高压氧治疗，对照组仅采取降压药物治疗，观察两组治疗后3个月的血压控制情况，并对患者进行为期1年的随访观察，观察患者心脏病发作的发生情况。结果：治疗前试验组和对照组的24h平均收缩压（mSBP）、24h平均舒张压（mDBP）、日间平均收缩压（dSBP）、日间平均舒张压（dDBP）、夜间平均收缩压（nSBP）和夜间平均舒张压（nDBP）测定值差异均无统计学意义（P>0.05）；治疗后试验组的mSBP、mDBP、dSBP、dDBP、nSBP、nDBP测定值显著低于对照组（P<0.05）。治疗前试验组和对照组的一氧化氮（NO）、内皮素-1（ET-1）测定值差异均无统计学意义（P>0.05）；治疗后试验组NO测定值显著高于对照组（P<0.05），ET-1测定值显著低于对照组（P<0.05）。对两组患者进行1年随访观察，试验组心脏并发症发生率为9.43%，与对照组的21.15%差异无统计学意义（P>0.05）。结论：降压药物联合高压氧治疗原发性高血压的降压效果更加显著，对并发症减少效果不明显，需要进一步延长随访时间。

Objective:To investigate the clinical effect of antihypertensive drugs combined with hyperbaric oxygen therapy in the treatment of primary hypertension and reducing the incidence of complicated complications Methods:From January 2014 to January 2015, 110 patients with primary hypertension disease were randomly divided into experimental group(n=55) and control group(n=55). The control group received antihypertensive drugs and the experimental group accepted hyperbaric oxygen therapy based on the control group. Blood pressure was collected before and after treatment. The incidence of complicated complications were observed within 1 year followed up. Results:Before treatment, the 24h mean systolic blood pressure (mSBP), 24h mean diastolic blood pressure (mDBP), daytime systolic blood pressure (dSBP), daytime mean diastolic blood pressure (dDBP), nighttime systolic blood pressure (nSBP), nighttime diastolic blood pressure (nDBP), nitric oxide (NO) and endothelin-1 (ET-1) had no significant differences within two groups(P>0.05). After treatment, all blood pressures and ET-1 had decreased, NO had increased in two groups(P<0.05). Compared with the control group, all blood pressures and ET-1 had decreased, NO had increased in experiment groups(P<0.05). The complicated complications after 1 year's follow-up had no significant differences between two groups(9.43% vs 21.15%, P>0.05). Conclusion:The antihypertensive drugs combined with hyperbaric oxygen can be used in treatment of primary hypertension, but the reduction of complications is not obvious, which need further research.

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