培美曲塞+顺铂方案同步放疗治疗局部晚期非鳞非小细胞肺癌的临床观察-东南大学学报医学版

培美曲塞+顺铂方案同步放疗治疗局部晚期非鳞非小细胞肺癌的临床观察

单位：徐州医科大学附属淮安医院放疗科, 江苏淮安 223002

分类号：R734.2;R815.6

出版年·卷·期（页码）：2017·36·第六期（912-915）

摘要：

目的：探讨培美曲塞+顺铂方案同步放疗对局部晚期非鳞非小细胞肺癌的近期疗效及安全性。方法：将68例非鳞非小细胞肺癌患者随机分为观察组与对照组，观察组采用培美曲塞+顺铂方案化疗同步调强放疗，对照组采用依托泊苷+顺铂方案化疗同步调强放疗，所有患者后续按原方案化疗2个周期，随访3个月，比较两组的近期疗效及安全性。结果：观察组有效率及疾病控制率分别为76.47%、94.12%，均高于对照组，差异有统计学意义（P<0.05）；观察组白细胞减少、恶心呕吐发生率均低于对照组，差异有统计学意义（P<0.05）。血红蛋白减少、血小板减少及肝功能损害的发生率两组均在50%以下，差异均无统计学意义（P>0.05）。结论：培美曲赛+顺铂方案同步放疗对局部晚期非鳞非小细胞肺癌近期疗效明确，患者可耐受，可作为一线可选方案。

Objective: To study the short-term efficiency and safety of pemetrexed plus cisplatin concurrent radiotherapy for locally advanced non-squamous-non-small cell lung cancer.Methods: Sixty-eight cases of non-squamous-non-small-cell lung cancer were divided into the observation group and the control group randomly. The observation group were given pemetrexed plus cisplatin concurrent intensity modulated radiotherapy, while the control group were given etoposide plus cisplatin concurrent intensity modulated radiotherapy. Then all the patients received sequential chemotherapy following previous regimens and followed-up for 3 months. The short-term efficiency and safety was compared between the two groups. Results: Efficiency rate and disease control rate of the observation group were 76.47% and 94.12% respectively, higher than those of the control group(52.94% and 76.47%), the difference were statistically significant(P<0.05). The incidence of leukocytopenia and nausea and vomiting of the observation group were 85.29% and 58.82%, lower than those of the control group, with statistical difference(P<0.05). The incidence of decreased hemoglobin, thrombocytopenia and liver damage in the two groups were all below 50%, without statistical difference(P>0.05).Conclusion: The short-term efficiency and safety of pemetrexed plus cisplatin concurrent radiotherapy for locally advanced non-squamous-non-small cell lung cancer are certain, they can be selected as first-line regimen.

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