>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
帕金森病患者伴发疲劳的相关因素的研究
作者:汪跃春  王玉琴  陈翔  季秋虹 
单位:南通大学附属医院 神经内科, 江苏 南通 226001
关键词:帕金森病 疲劳 相关因素 
分类号:R742.5
出版年·卷·期(页码):2017·36·第六期(915-918)
摘要:

目的:研究帕金森病(PD)患者伴发疲劳的情况及其相关因素。方法:以97例PD患者为研究对象,应用疲劳严重程度量表对患者进行疲劳评估。记录所有患者统一帕金森病量表(UPDRS)评分,Hoehn-Yahr(H-Y)分期,Beck焦虑量表(BAI)、Beck抑郁量表(BDI)、帕金森病睡眠量表(PDSS)、39项PD问卷(PDQ-39)评分及左旋多巴等效剂量(LED),比较疲劳组和非疲劳组之间是否存在差异。结果:97例患者中,63例(63.9%)存在疲劳。UPDRS评分,H-Y分期,BAI、BDI、PDSS、PDQ-39评分及LED与疲劳相关。Logistic回归分析显示,BDI和PDSS评分是疲劳的独立危险因素。结论:PD患者疲劳的发生率高,抑郁和睡眠障碍是影响疲劳的主要因素,严重影响患者的生活质量。

Objective: To investigate the prevalence of fatigue and its associated factors in the patients with Parkinson disease(PD). Methods: Ninety-seven patients with PD were enrolled in this research. Fatigue severity scale was used to evaluate whether the fatigue exist or not. All patients were assessed by the unified PD rating scale(UPDRS), Hoehn-Yahr stage, Beck anxiety inventory(BAI), Beck depression inventory(BDI), PD sleep scale(PDSS),PD questionnaire-39(PDQ-39) and levodopa equivalent dose(LED),and the results were comparison between the fatigue group and the non-fatigue group. Results: Of the 97 patients,63(63.9%) were defined as fatigue.UPDRS,Hoehn-Yahr stage,the scores of BAI, BDI, PDSS, PDQ-39 and LED, were associated with fatigue. Binary-Logistic regression analysis showed that the scores of BDI and PDSS were independent risk factors for fatigue in patients with PD. Conclusion: Patients with PD have high incidence of fatigue.Depression and sleep disorder are correlated with fatigue, and it significantly influences the quality of life.

参考文献:

[1] 中华医学会神经病学分会运动障碍及帕金森病学组.帕金森病的诊断[J].中华神经科杂志,2006,39(6):408-409.
[2] BROWN R G,DITTNER A,FINDLEY L,et al.The Parkinson fatigue scale[J].Parkinsonism Relat Disord,2005,11(1):49-55.
[3] DEUSCHL G,SCHADE-BRITTINGER C,KRACK P,et al.A randomized trial of deep-brain stimulation for Parkinson's disease[J].N Engl J Med,2006,355(9):896-908.
[4] BEISKE A G,SVEUSSON E.Fatigue in Parkinson's disease:a short update[J].Acta Nurol Scand,2010,122(Suppl 190):78-81.
[5] BARONE P,ANTONINI A,COLOSIMO C,et al.The PRIAMO study:A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease[J].Mov Disord,2009,24:1641-1649.
[6] MONIKA G J,DARIUSZ K,KRZYSATOF S,et al.Risk factors of fatigue in idiopathic Parkinson's disease in a polish population[M]//JAN A,CRISTINE A,IVAN B W,et al.Parkinson's disease.Cairo:Hindawi Publishing Corporation,2016:1-8.
[7] HERLOFSON K,LARSEN J P.Measuring fatigue in patients with Parkinson's disease-the Fatigue Severity Scale[J].Eur J Neurol,2002,9(6):595-600.
[8] 楼跃,肖勤,陈生第.帕金森病疲劳的相关因素研究[J].老年医学与保健,2012,18(2):76-78.
[9] SCHULMAN L M,TABACK R L,BEAN J,et al.Comorbidity of the nonmotor symptoms of Parkinson's disease[J].Mov Disord,2001,16(3):507-510.
[10] BEISKE A G,LOGE J H,HJERMSTAD M J,et al.Fatigue in Parkinson's disease:prevalence and associated factors[J].Mov Disord,2010,25(14):2456-2460.
[11] ZUO L J,YU S Y,WANG F,et al.Parkinson's disease with fatigue:clinical characteristics and potential mechanisms relevant to α-synuclein oligomer[J].J Clin Neurol,2016,12(2):172-180.
[12] LOU J S,KEARNS G,BENICE T,et al.Levodopa improves physical fatigue in Parkinson's disease:a double-blind,placebo-controlled,crossover study[J].Mov Disord,2003,18(10):1108-1114.
[13] SCHIFITTO G,FRIEDMAN J H,OAKES D,et al.Fatigue in levodopa-naive subjects with Parkinson's disease[J].Neurology,2008,71(7):481-485.
[14] PAVESE N,METTA V,BOSE S K,et al.Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction[J].Brain,2010,133(11):3434-3443.
[15] KLUGER B M,HERLOFSON K,CHOU K L,et al.Parkinson's disease-related fatigue:A case definition and recommendations for clinical research[J].Mov Disord,2016,31(5):625-631.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 405478 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-83272481 83272483
电子邮件:
bjb@pub.seu.edu.cn

苏ICP备09058364