彩色多普勒超声、HbA1c及hs-CRP联合检测对动脉粥样硬化脑梗死的诊断价值-东南大学学报医学版

彩色多普勒超声、HbA1c及hs-CRP联合检测对动脉粥样硬化脑梗死的诊断价值

单位：1. 徐州医科大学第二附属医院影像科, 江苏徐州 221006;
2. 徐州医科大学第二附属医院检验科, 江苏徐州 221006;
3. 徐州医科大学第二附属医院神经内科, 江苏徐州 221006

分类号：R743.33

出版年·卷·期（页码）：2018·37·第一期（60-63）

摘要：

目的：探讨彩色多普勒超声、糖化血红蛋白A1（HbA1c）及超敏C反应蛋白（hs-CRP）联合检测在动脉粥样硬化脑梗死中的诊断价值。方法：选择我院2014.01~2017.01期间收治的85例脑梗死患者为观察组及40例健康人群为对照组，比较两组患者HbA1c、hs-CRP和IMT水平；依据IMT值将患者分为正常、轻度和重度动脉粥样硬化组，按照NIHSS评分将患者分为轻度、中度和重度神经功能障碍组，并比较不同分组之间HbA1c、hs-CRP水平。结果：观察组斑块检出率、HbA1c、hs-CRP和IMT值均显著高于对照组（P < 0.05）；稳定斑块组HbA1c、hs-CRP、IMT和同侧脑梗死发生率均显著低于不稳定斑块组（P < 0.05）；轻度、中度和重度神经功能障碍组及正常、轻度和重度动脉粥样硬化组HbA1c和hs-CRP水平组间两两比较差异显著（P < 0.05），其中，重度最高。结论：HbA1c和hs-CRP结合颈动脉彩超检测有助于指导动脉粥样硬化脑梗死患者的临床治疗和预后。

Objective: To investigate the diagnostic value of HbA1c and hs-CRP combined with carotid ultrasonography in atherosclerotic cerebral infarction. Methods: 85 patients with cerebral infarction admitted from January 2014 to January 2017 were taken as observation group,40 healthy people in our hospital were taken as control group, the levels of HbA1c, hs-CRP and hs-CRP were compared in two groups. Patients were divided into normal, mild and severe atherosclerosis patients according to the IMT values, and into mild, moderate and severe neurological dysfunction according to the NIHSS score,their HbA1c,hs-CRP levels were compared. Results: HbA1c, hs-CRP, IMT values in the observation group were significantly higher than those of the control group (P<0.05); The incidence of ipsilateral cerebral infarction, HbA1c, hs-CRP, IMT in the patients with stable plaque were significantly lower than those with unstable plaques (P<0.05);The difference of HbA1c and hs-CRP between the patients with mild, moderate and severe neurological dysfunction, and normal, mild and severe atherosclerosis patients were statistically significant (P<0.05) among which the highest degree was in the severe patients. Conclusion: HbA1c and hs-CRP combined with carotid ultrasonography can be helpful in guiding the clinical treatment and prognosis in patients with atherosclerotic cerebral infarction.

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