>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
子宫内膜癌患者癌组织中核连蛋白-2表达与临床病理特征及预后的相关性分析
作者:钱卫卫  冯文 
单位:连云港市第一人民医院 妇科, 江苏 连云港 222002
关键词:子宫内膜癌 核连蛋白-2 临床病理特征 预后 
分类号:R737.33
出版年·卷·期(页码):2018·37·第四期(572-577)
摘要:

目的:探讨子宫内膜癌患者癌组织中核连蛋白-2(nucleobindin-2)表达与临床病理特征及预后的相关性。方法:选取本院妇科确诊的98例子宫内膜癌患者为子宫内膜癌组,同时设置正常子宫内膜组(24例)、复杂性增生病例组(36例)、子宫内膜不典型增生病例组(42例),采用酶联免疫吸附法及免疫组化方法测定各组nucleobindin-2表达。结果:复杂性增生组、子宫内膜不典型增生组、子宫内膜癌组nucleobindin-2表达水平高于正常子宫内膜组,且子宫内膜不典型增生组nucleobindin-2表达水平高于复杂性增生组,子宫内膜癌nucleobindin-2表达水平高于复杂性增生组、子宫内膜不典型增生组,差异均有统计学意义(t=10.231、11.343、13.432、12.453、10.871、11.094,均P<0.05);正常子宫内膜组、复杂性增生组、子宫内膜不典型增生组、子宫内膜癌组nucleobindin-2阳性率逐渐升高,且差异有统计学意义(χ2=26.241,P<0.05)。子宫内膜癌患者nucleobindin-2表达与年龄相关性不明显,差异无统计学意义(χ2=0.232,P>0.05);与病理分型、病理学分级、TMN分期、浸润深度、淋巴血管间隙浸润、淋巴结转移相关性明显,且子宫内膜样腺癌、病理学分期越高、TMN分期越高、浸润深度越深、有淋巴血管间隙浸润、有淋巴结转移,nucleobindin-2阳性表达率越高,差异有统计学意义(χ2=6.112、20.312、10.121、24.152、7.723、8.734,P<0.05或P<0.01)。nucleobindin-2阴性组3年生存率及生存期均明显高于nucleobindin-2阳性组,差异有统计学意义(χ2=14.697、12.993,P<0.05)。结论:nucleobindin-2在子宫内膜癌组织的表达量高于正常子宫内膜组织,nucleobindin-2在子宫内膜癌的发生发展过程中起促进作用;nucleobindin-2低表达的患者能获得较好的预后。

Objective:To investigate the expression of nucleobindin-2 protein in cancer tissue and its correlation with clinicopathological features and prognosis of patients with endometrial carcinoma. Methods:98 cases with endometrial cancer gynecology diagnosed in our hospital were selected as the endometrial cancer group, and 24 cases with normal endometrium, 36 cases with complex hyperplasia by surgical resection or outpatient cases, and 42 cases of endometrial atypical hyperplasia scraping were selected.The enzyme-linked immunosorbent assay and immunohistochemical method were used to detect the expression of nucleobindin-2 protein. Results:The expression level of nucleobindin-2 protein in complex hyperplasia group, atypical endometrial hyperplasia group and endometrial cancer group were higher than that of normal endometrium group, and the expression level of atypical endometrial hyperplasia group was higher than that in complex hyperplasia group, the expression of nucleobindin-2 protein in endometrial cancer group was higher than that of complex hyperplasia group and atypical endometrial hyperplasia group, the differences were statistically significant (t=10.231, 11.343, 13.432, 12.453, 10.871, 11.094, P<0.05).The nucleobindin-2 positive rate were gradually increased in the normal endometrium group, complex hyperplasia group, atypical endometrial cancer group and endometrial hyperplasia group, and the difference were statistically significant (χ2=26.241, P<0.01).The relationship between the expression of nucleobindin-2 protein and age was not obvious(χ2=0.232, P>0.05). The expression level of nucleobindin-2 protein was positively correlated with pathological grade, pathological types, TMN stage, invasion depth, lymph vascular space invasion, lymph node metastasis, and the higherpathological staging, the higher the stage of TMN, the depth of invasion deeper, lymph vascular space invasion, lymph node metastasis, the higherexpression rate of nucleobindin-2, and the difference were statistically significant (χ2=6.112, 20.312, 10.121, 24.152, 7.723, 8.734, P<0.05 or P<0.01).The 3 years survival rate and survival time nucleobindin-2 in the negative group were significantly higher than that in the nucleobindin-2 positive group, the difference was statistically significant (χ2=14.697, 12.993, P<0.05). Conclusion:The expression of nucleobindin-2 protein in endometrial carcinoma is higher than that in normal endometrial tissue.The nucleobindin-2 protein play an important role in the occurrence and development of endometrial cancer.The patients with low expression of nucleobindin-2 protein can obtain better prognosis.

参考文献:

[1] 姚玮,卫兵,付娟娟,等.子宫内膜癌患者人附睾蛋白4含量变化及其与肿瘤组织中凋亡分子表达的相关性[J].安徽医学,2017,38(7):23-24.
[2] 别延红,李纳,吴又明,等.转录因子增强子结合蛋白-4基因沉默对子宫内膜癌细胞凋亡的影响[J].山东医药,2017,57(2):5-9.
[3] HOFMANN T,WEIBERT E,AHNIS A,et al.Alterations of circulating NUCB2/nesfatin-1 during short term therapeutic improvement of anxiety in obese inpatients[J].Psychoneuroendocrinology,2017,79(5):107-115.
[4] 陈晓燕.MMP-14和Ezrin在子宫内膜癌中的表达和临床意义分析[J].检验医学与临床,2017,14(9):1344-1346.
[5] WANG C,WANG Y,HU W.Association of the polymorphism in NUCB2 gene and the risk of type 2 diabetes[J].Diabetol Metab Syndr,2017,9(1):39-40.
[6] 王丽,张勇.SRPX2在子宫内膜癌中的表达及对HEC-1A细胞增殖凋亡的影响[J].实用医学杂志,2017,33(4):529-532.
[7] GAWLI K,RAMESH N,UNNIAPPAN S.Nesfatin-1-like peptide is a novel metabolic factor that suppresses feeding,and regulates whole-body energy homeostasis in male Wistar rats[J].PLoS One,2017,12(5):329-330.
[8] 王晨,孔为民.子宫内膜癌雌激素受体、孕激素受体及原癌蛋白表达状态与临床病理特征关系的研究[J].中国临床医生杂志,2017,45(7):97-100.
[9] 李美艳.骨桥蛋白在子宫内膜癌组织中的表达及对预后的影响[J].河北医科大学学报,2017,38(2):168-172.
[10] MORI Y,SHIMIZU H,KUSHIMA H,et al.Increased blood pressure in nesfatin/nuclebindin-2-transgenic mice[J].Hypertens Res,2017,11(6):245-247.
[11] 吴媛.子宫内膜癌中淀粉样肽前体样蛋白2表达变化及对预后的影响分析[J].河北医药,2017,39(7):995-997.
[12] 杨胜利,曹芳芹,郭粉莉,等.子宫内膜癌组织中GDF-15和p-mTOR蛋白的表达及临床意义[J].现代生物医学进展,2017,17(5):913-915.
[13] 余娜,伍科,庄研,等.miR-26a-5p通过靶向THAP2促进子宫内膜癌细胞凋亡[J].现代妇产科进展,2017,26(5):321-324.
[14] 李永梅,杨焕莲,刘玉元.β-抑制蛋白2及Toll样受体2在子宫内膜癌中的表达及关系研究[J].中国妇幼保健,2016,31(12):2544-2546.
[15] 孙利华,汪蕾.miRNA-21靶向调控子宫内膜癌PTEN基因MRE-21片段的研究[J].现代医学,2017,45(10):1442-1446.
[16] 杨蓉娟,宋春红,许艳蕾,等.hTERT反义寡聚核苷酸对子宫内膜癌细胞Bcl-2蛋白含量的影响[J].河北医药,2016,38(9):1306-1308.
[17] 吴宝萍,徐锦媚,刘颖,等.下调ZNF139表达对子宫内膜癌细胞RL95-2增殖和凋亡的影响及其机制[J].现代肿瘤医学,2016,24(16):2516-2520.
[18] 饶云霞.子宫内膜癌患者血清HE4、CP2、HCgp-39含量与肿瘤恶性程度的关系探究[J].海南医学院学报,2017,23(4):444-447.
[19] 李莉,刘巧玲.血清β-hCG、孕酮水平及子宫内膜厚度检测对早期不明位置妊娠者异位妊娠的诊断价值[J].现代医学,2016,44(12):1768-1771.
[20] HATEF A,UNNIAPPAN S.Gonadotropin-releasing hormone,kisspeptin,and gonadal steroids directly modulate nucleobindin-2/nesfatin-1 in murine hypothalamic gonadotropin-releasing hormone neurons and gonadotropes[J].Biol Reprod,2017,96(3):636-637.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 150886 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-87232483 83272481
电子邮件:
bjb@pub.seu.edu.cn

苏ICP备09058364