Objective:To explore the clinical study of neoadjuvant chemotherapy efficacy and prognosis in the application of multicenter multidisciplinary treatment for locally advanced non-small cell lung cancer (NSCLC) patients.Methods:The patients with NSCLC were randomly collected and divided into the study group (n=55) and the control group (n=55) from March 2013 to July 2015 in our hospital. The single center standard treatment model was used in the control group, and multicenter MDT model was applied in the study group. The clinical efficiency, clinical and prognosis correlation indexes were compared between the two groups using statistical analysis. Results:Compared to the control, the size of mediastinal lymph nodes decreased more significantly after chemical treatment in the study group(P<0.05). After two weeks treatment,the effective rate in the study group(69.1%)was significantly higher than that in the control group(41.8%)(P<0.05). Compared with the control group, the average hospital cost, the length of stay, the VAS scores were lower in the study group(P<0.05). Although there was no significant difference for the 1-year survival rate between the two groups (P>0.05), the survival rate of the study group (65.5%) was higher than that of the control group (50.9%),while PFS in the study was more than that of the control group (P<0.05). Additionally, there was no significant difference in serum prognosis between the two groups before treatment. However, after treatment,the serum prognostic markers of the two groups decreased,and the levels in the study group were lower than those of the control group (P<0.05). The FACT-L scores in the study group were also higher than that of the control group after treatment(P<0.05). Conclusion:The multicenter multidisciplinary team model is an effective measure for locally advanced NSCLC patients, which helps patients to improve the effective rate,the quality of life and the prognosis. Therefore, this model should be widely applied in clinical treatment. |
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