Objective:To evaluate the left ventricular diastolic function in patients with type 2 diabetes mellitus(T2DM) using mitral annulus displacement automatic tracking (MAD) and real-time three-dimensional echocardiography (RT-3DE). Methods:54 patients with T2DM were divided into two groups according to the course of disease:DM group 1(n=26) with a course less than or equal to 5 years,DM group 2(n=28) with a course more than 5 years; 27 healthy volunteers were selected as the control group. MAD was used to measure early diastolic (De) and late diastolic (Da) shifts at the posterior septum,lateral wall, anterior wall, inferior wall of the mitral valve annulus,and early mean displacement (EDefour-chamber, EDetwo-chamber), late diastolic mean displacement (EDafour-chamber, EDAtwo-chamber), double-plane of left ventricular diastolic's early mean displacement (EDedouble-plane), late diastolic mean displacement (EDadouble-plane).Left ventricular ejection fraction (LVEF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and left ventricular peak filling rate (PFR) were calculated by using RT-3DE.Compared the differences between all groups. Results:There were significant differences between De and EDefour-chamber, EDetwo-chamber, and EDedouble-plane between the four sites of posterior septum,lateral wall, anterior wall, and inferior wall of mitral annulus (P<0.05). There was no significant difference in Da and EDafour-chamber, EDatwo-chamber,and EDadouble-plane in the four sites of the mitral valve annulus (P>0.05). There was a statistically significant difference in PFR between groups (P<0.05). There was no significant difference in LVEF,EDV, ESV, and SV between groups (P>0.05).There was a positive correlation between EDedouble-plane and PFR (r=0.608, P=0.000), but there was no significant correlation between EDadouble-plane and PFR (r=-0.130, P=0.348). Conclusion:Left ventricular diastolic dysfunction in patients with T2DM is earlier than systolic dysfunction. MAD and RT-3DE have a good correlation in evaluating left ventricular global and local diastolic function in T2DM patients. |
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