目的：探讨AEG-1调控eIF4E表达促进胃癌细胞迁移的作用机制。方法：在SGC7901胃癌细胞株上用质粒转染或siRNA转染的方法过表达或沉默AEG-1的表达，用Western blotting法检测eIF4E及上皮-间质样转化（EMT）的标志物表达的变化，用transwell实验检测胃癌细胞的迁移。结果：过表达AEG-1诱导SGC7901细胞发生EMT，同时上调eIF4E的表达；沉默AEG-1的表达抑制细胞发生EMT，同时下调eIF4E的表达；沉默AEG-1的表达抑制CXCL12诱导的细胞迁移，同时下调eIF4E的表达；过表达eIF4E部分逆转由于沉默AEG-1的表达引起的胃癌细胞迁移的抑制作用。结论：AEG-1通过上调eIF4E表达促进胃癌细胞的迁移。

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