增生性瘢痕是指皮肤烧伤或创伤后等真皮网状层的损伤，导致组织过度修复，细胞外基质异常沉积所导致的一种病理性瘢痕。临床表现多有局部变硬增厚，表面紫红或潮红，并伴有不同程度的瘙痒，早期易形成水泡，导致瘢痕溃疡。此外，还致使外观受损，甚至严重的机体功能受限。因此，增生性瘢痕的防治尤为重要。目前，主要的防治手段分为手术治疗和非手术治疗，临床上压力疗法、激光辅助皮质类固醇激素注射疗法以及有机硅凝胶疗法较为常用，近期一些新兴的替代疗法也日渐受到重视。

[1] RABELLO F B,SOUZA C D,FARINA J A.Update on hypertrophic scar treatment[J].Clinics,2014,69(8):565-573.
[2] 刘茹太洋,范金财.增生性瘢痕及瘢痕疙瘩的治疗流程[J].中国美容整形外科杂志,2017,28(10):636-638.
[3] 房渊,郝平,张辉,王曙曼.瘢痕疙瘩的治疗新进展[J].临床医药实践,2018,27(3):216-221.
[4] Finnerty C C,Jeschke M G,Branski L K,et al.Hypertrophic scarring:The greatest unmet challenge after burn injury[J].Lancet,2016,388(10052):1427-1436.
[5] 王达利,增生性瘢痕防治的研究进展与方向[J].中华损伤与修复杂志:电子版,2017,11(4):247-253.
[6] 吴登艳,邓娅,郝进,等.PI3K/AKT/mTOR信号通路介导黄芩苷抑制增生性瘢痕组织成纤维细胞的增殖[J].中国生物化学与分子生物学报,2014,30(1):60-67.
[7] 宋菲,刘英开,王西樵.增生性瘢痕发生和演变过程中微血管和氧分压动态变化的研究[J].上海交通大学学报:医学版,2016,36(11):1553-1557.
[8] RODRIGUEZ P G,FELIX F N,WOODLEY D T,et al.The role of oxygen in wound healing:a review of the literature[J].Dermatol Surg,2008,34(9):1159-1169.
[9] 李战,农晓琳,李佳荃,等.青蒿琥酯对增生性瘢痕成纤维细胞的抑制作用及机制探讨[J].中国药理学通报,2014,30(7):947-951.
[10] CANDY L H,CECILIA L T,PING Z Y.Effect of different pressure magnitudes on hypertrophic scar in a Chinese population.Burns,2010,36(8):1234-1241.
[11] AIJ W,LIU J T,PEI S D,et al.The effectiveness of pressure therapy (15-25 mmHg) for hypertrophic burn scars:A systematic review and meta-analysis[J].Sci Rep,2017,7:40185.
[12] WIROHADIDOJO Y W,RADIONO S,BUDIYANTO A,et al.Cellular viability,collagen deposition,and transforming growth factor beta1 production among ultraviolet B-irradiated keloid fibroblasts[J].Aesthetic Plast Surg,2011,35(6):1050-1055.
[13] TAUDORF E H,DANIELSEN P L,PAULSEN I F,et al.Non-ablative fractional laser provides long-term improvement of mature burn scars-A randomized controlled trial with histological assessment[J].Lasers Surg Med,2015,47(2):141-147.
[14] HAYASHI T, FURUKAWA H, OYAMA A,et al.A new uniform protocol of combined corticosteroid injections and ointment application reduces recurrence rates after surgical Keloid/Hypertrophic scar excision[J].Dermatol Surg,2012,38(6):893-897.
[15] GOLD M H,MCGUIRE M,MUSTOE T A,et al.Updated international clinical recommendations on scar management:part 2--algorithms for scar prevention and treatment[J].Dermatol Surg,2014,40(8):825-831.
[16] TANDARA A A,MUSTOE T A.The role of the epidermis in the control of scarring:Evidence for mechanism of action for silicone gel[J].J Plast Reconstr Aesthet Surg,2008,61(10):1219-1225.
[17] 宋溦,黄东,王玥莹,增生性瘢痕诊治的研究进展.现代医院,2015,15(5):16-19.
[18] CHO J W,CHO S Y,LEE S R,et al.Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo[J].Int J Mol Med,2010,25(3):347-352.
[19] 蔡明达,胡大海,刘佳琦.增生性瘢痕防治的研究进展[J].中国医药导报,2015,12(35):31-34.