Objective: To observe the clinical effect of Jinghuang Ointments in the treatment of external humeral epicondylitis. Methods: 80 patients who met the inclusion criteria were randomized and divided into a treatment group and a control group, with 40 in each group. The treatment group was given external application of Jinghuang Ointments, and the control group was externally applied with placebo, both arms were suspended and fixed. Both groups were treated for 2 weeks. The efficacy was evaluated and judged according to the SF-McGill scale score of the elbow and the therapeutic standard of diagnosis and treatment of TCM syndrome before treatment, 1 week after treatment, and 2 weeks after treatment. Results: Before treatment, there was no significant difference in the SF-McGill scale between the treatment group and the control group (P>0.05). After 1 week of treatment and 2 weeks after treatment, the SF-McGill scale scores of both groups showed a downward trend. One week and 2 weeks after treatment, the SF-McGill scale was significantly different between the treatment group and the control group (P<0.01). After analysis of variance of repeated measures, the results showed that the treatment effect at different times was statistically significant (P<0.01). The SF-McGill scale score presented a time-dependent decreasing trend in the two groups. The interaction between drug and time was statistically significant (P<0.01). There was a statistically significant difference between the 1 week and 2 weeks after treatment (P<0.01). According to the SF-McGill scale score, the effect of Jinghuang Ointments was better than that of placebo, and the difference was statistically significant (P<0.01). The total effective rate of treatment group was 90%,while the control group was37.50%. The total effective rate of control group was significantly lower than that of the treatment group (P<0.01). Conclusion: External application of Jinghuang Ointments in the treatment of external humeral epicondylitis can significantly reduce pain and improve joint activity. It is worthy of clinical promotion because of its simple operation, low price, safety and little side effects. |
[1] DA COSTA J T,BAPTISTA J S,VAZ M.Incidence and prevalence of upper-limb work related musculoskeletal disorders:a systematic review[J].Work,2015,51(4):635-644.
[2] 代飞,向明.肱骨外上髁炎病因与发病机制的研究进展[J/OL].中华肩肘外科电子杂志,2017,5(2):142-144.
[3] AHMAD Z,SIDDIQUI N,MALIK S S,et al.Lateral epicondylitis:a review of pathology and management[J].Bone Joint J,2013,95(9):1158-1164.
[4] 中华医学会.临床诊疗指南-骨科分册[M].北京:人民卫生出版社,2009:65.
[5] 吴飞,陆章琪,胡佳亮,等.临床试验用中药安慰剂设计和质量控制研究进展[J].中国新药杂志,2018,27(11):1254-1261.
[6] MELZACK R.The McGill pain questionnaire:major properties and scoring methods[J].Pain,1975,1(3):277-299.
[7] 中医病证诊断疗效标准[M].北京:中国医药科技出版社,2012:195.
[8] GROPPEL J L,NIRSCHL R P.A mechanical and electromyographical analysis of the effects of various joint counterforce braces on the tennis player[J].Am J Sports Med,1986,14(3):195-200.
[9] KRAUSHAAR B S,NIRSCHL R P.Tendinosis of the elbow (tennis elbow):clinical features and findings of histological,immunohistochemical,and electron microscopy studies[J].JBJS,1999,81(2):259.
[10] 郑华江,曹进,仲肇平.体外冲击波联合耳穴疗法治疗肱骨外上髁炎35例[J].中国中医骨伤科杂志,2018,26(12):63-64,67.
[11] 王艳杰,吴骁,孙育良.自体富血小板血浆与全血局部注射治疗网球肘的疗效比较[J].中国临床研究,2018,31(4):527-530.
[12] 李琪,李豹,蔡春元,等.肘关节镜结合小切口清理修补术根治顽固性网球肘[J].中国骨伤,2018,31(9):812-817.
[13] 张方辉.如意金黄散化裁在外科临床应用综述[J].内蒙古中医药,2017,36(Z1):214-216.
[14] 谭鹏,张海珠,李洋,等.基于活血生物效价检测大黄中10个蒽醌类成分抗血小板聚集作用初步研究[J].中草药,2018,49(4):859-865.
[15] 任星宇,罗敏,邓才富,等.白芷挥发油提取方法及药理作用的研究进展[J].中国药房,2017,28(29):4167-4170.
[16] 陆小华,马骁,王建,等.赤芍的化学成分和药理作用研究进展[J].中草药,2015,46(4):595-602.
[17] 中华中医药学会.肱骨外上髁炎[J].风湿病与关节炎,2013,2(3):77-78.
[18] 吕祥,夏英,凌丽,等.中药新药临床试验安慰剂应用的思考[J].中国临床药理学杂志,2018,34(18):2238-2240.
[19] 武振宇,郑雪莹.安慰剂对照在临床研究设计教学中的探讨[J].中国卫生统计,2017,34(3):526-527.
[20] 郑航,郭慧琳,唐亚岚,等.《赫尔辛基宣言》安慰剂使用原则的修订历程及启示[J].医学与哲学,2018,39(7):37-39. |