Objective: To explore the clinicopathologic features and differential diagnosis of extra-adrenal paraganglioma. Method:The clinical and histopathologic features of 15 cases of extra-adrenal paraganglioma confirmed by our department were analyzed and the related literatures was reviewed. Results: Among these 15 patients,5 were male and 10 were female aged from 16 to 74 years.The tumors were located in retroperitoneal,vertebral,neck, bladder,scrotum and vagina, respectively. Tumor were composed of oval or polygonal main cell and sustentacular cells which surrounded the main cell. The cells arranged in Zellballen or cellular. All cases were benign. Immunohistochemical investigations revealed main cells were positive for neuron specific endolase, chromogranin A, synaptophysin, but negative for cytokeratin,epithelial membrane antigen. Sustentacular cells were positive for S-100 protein. Conclusion: Extra-adrenal paraganglioma can arise in any location in adult tissues. Awareness of the existence of extra-adrenal paraganglioma in unusual locations will reduce errors in diagnosis. |
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