Objective: To investigate the effect of neoadjuvant chemotherapy on early postoperative pain and perioperative recovery in patients with advanced gastric cancer. Methods: A retrospective analysis method was used to collect clinical data of patients with advanced gastric cancer who underwent radical gastric cancer surgery between January 2017 and December 2018. A total of 74 patients aged 18 years or more with ASA grade Ⅱ-Ⅲ were enrolled. According to whether the patients received neoadjuvant chemotherapy, they were divided into the neoadjuvant chemotherapy group(group N, n=35) and the control group(group C, n=39). Patients in group N received FOLFOX chemotherapy, and radical gastric cancer surgery was performed 2 weeks after chemotherapy. The two groups of patients received identical anesthesia plans. We recorded the general conditions of the patients, time of tracheal extubation, time of stay in the postanaesthesia care unit(PACU), 6, 24, 48, 72 h postoperative pain numerical rating scale, number of cases of rescue analgesics, length of postoperative hospital stay and adverse reactions. Results: Compared with patients in group C, patients in group N had significantly higher NRS at 24 h, 48 h, and 72 h after surgery, longer time of tracheal extubation, longer PACU stay time, larger numbers of postoperative rescue analgesics, and longer postoperative hospital stays(all P<0.05). There was no significant difference in the time of initial postoperative defecation and the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Neoadjuvant chemotherapy can increase the pain intensity and the use of analgesics in the early postoperative period of radical gastric cancer patients, prolong the tracheal tube extraction time, PACU stay time and the postoperative hospital stay, but does not increase related adverse reactions. |
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