Objective: To explore the expression level of galectin-1 (Gal-1) in lung cancer tissues, analyze its relationship with clinical characteristics and its prognostic value.Methods: A total of 130 lung cancer patients admitted to our hospital from January 2018 to January 2020 were selected for research. Immunohistochemistry was used to detect the expression of Gal-1 in cancer tissues and adjacent tissues. The clinicopathological data of patients were collected to analyze the relationship between Gal-1 expression and pathological features. Cox multiple regression model was used to analyze the factors affecting the prognosis of lung cancer patients. From the 1st day after the operation as the starting day to the 12-month follow-up as the cut-off time, the overall survival rate of the patients was recorded.Results: The positive expression rate of Gal-1 in lung cancer tissues was 48.46%, which was higher than 15.38% in the adjacent tissues. In the Gal-1 positive group, the proportions of clinical stage Ⅲ, lymph node metastasis, and vascular invasion were 50.79%, 57.14%, and 38.10, respectively, whitch were higher than 22.39%, 19.40%, 16.42% of Gal-1 negative group (P < 0.05). COX multivariate analysis indicated that age ≥ 60 years, clinical stage Ⅲ, lymph node metastasis, pleural invasion, vascular invasion, and positive expression of Gal-1 were risk factors affecting the overall survival and tumor-free survival of patients (P < 0.05). The overall survival rate and tumor-free survival rate of the Gal-1 positive group were 66.67% and 63.49%, respectively, which were lower than 88.06% and 83.58% of the Gal-1 negative group (P < 0.05).Conclusion: The positive expression rate of Gal-1 in cancer tissues of patients with lung cancer is relatively high, and its expression may be related to clinical staging, lymph node metastasis, and vascular invasion. It is expected to become an important indicator of prognosis. |
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