Objective: To evaluate the relationship between the serum prolidase(PEPD) activity and malondialdehyde(MDA) level and the occurrence of attention deficit hyperactivity disorder(ADHD) in epileptic children. Methods: From February 2020 to April 2021, 122 children with idiopathic epilepsy admitted to our hospital were selected as study subjects, and another 60 healthy children during the same period were selected as control group. According to the occurrence of ADHD, children with epilepsy were divided into ADHD group and non-ADHD group. The PEPD activity, MDA level and total oxidation status(TOS) and oxidative stress index(OSI) were detected. Multivariate Logistic regression model and receiver operating characteristic curve(ROC) were used to analyze the relationship between PEPD activity, MDA level and ADHD in epileptic children. Results: Serum PEPD activity, MDA level, TOS and OSI in epilepsy group were higher than those in the control group(P<0.05). Serum PEPD activity, MDA level and OSI value in ADHD group were higher than those in non-ADHD group(P<0.05). In ADHD group, serum PEPD activity and MDA level were correlated with OSI level(r=0.505, 0.595, P<0.05). And serum PEPD activity and MDA level were independent risk factors affecting the risk of ADHD in children with epilepsy(P<0.05). The area under ROC curve of serum PEPD activity and MDA level were 0.817(95%CI0.741-0.894) and 0.760(95%CI0.674-0.847), respectively. Conclusion: Increased serum PEPD activity and MDA level are independent risk factors for ADHD in children with epilepsy. |
[1] ELHADY M,YOUNESS E R,MOSTAFA R S I,et al.Oxidative stress contribution to attention deficit hyperactivity disorder in children with epilepsy[J].Appl Neuropsychol Child,2019,8(4):347-354.
[2] 王龙飞,胡春辉,王华.儿童癫痫共患注意缺陷多动障碍临床特征及相关因素分析[J].中国实用儿科杂志,2018,33(4):276-280.
[3] KUL M,UNAL F,KANDEMIR H,et al.Evaluation of oxidative metabolism in child and adolescent patients with attention deficit hyperactivity disorder[J].Psychiatry Investig,2015,12(3):361-366.
[4] AKARİ,İ NCE İ,ASLAN C,et al.Oxidative stress and prolidase enzyme activity in the pathogenesis of primary varicose veins[J].Vascular,2018,26(3):315-321.
[5] LEPARA Z,LEPARA O,FAJKIC A,et al.Serum malondialdehyde(MDA) level as a potential biomarker of cancer progression for patients with bladder cancer[J].Rom J Intern Med,2020,58(3):146-152.
[6] 丁晶,汪昕.癫痫诊疗指南解读[J].临床内科杂志,2016,33(2):142-144.
[7] 黎素清,郑凤丽,谭志军,等.癫痫患儿血清及脑脊液CRP、S100B、NSE含量变化与临床意义[J].现代医学与健康研究,2020,4(5):84-85.
[8] BRIKELL I,GHIRARDI L,D'ONOFRIO B M,et al.Familial liability to epilepsy and attention-deficit/hyperactivity disorder:a nationwide cohort study[J].Biol Psychiatry,2018,83(2):173-180.
[9] CHOUDHARY A,GULATI S,SAGAR R,et al.Childhood epilepsy and ADHD comorbidity in an Indian tertiary medical center outpatient population[J].Sci Rep,2018,8(1):2670.
[10] BAYRAM M,DERIN M E,DOGAN H O,et al.High prolidase levels in patients with Familial Mediterranean Fever(FMF)[J].Rom J Intern Med,2020,58(1):27-33.
[11] AKTURK E,ASKIN L,NACAR H,et al.Association of serum prolidase activity in patients with isolated coronary artery ectasia[J].Anatol J Cardiol,2018,19(2):110-116.
[12] AYAS Z O,KOTAN D,AKDOGAN M,et al.Serum prolidase enzyme activity level:not a predictive biomarker for epilepsy[J].Eurasian J Med,2019,51(1):27-30.
[13] KARACAN N,ÇALIK M,KAZANASMAZ H,et al.The serum prolidase enzyme activity as a biomarker for evaluation of the subclinical vascular damage in children with epilepsy[J].Ann Indian Acad Neurol,2020,23(6):787-791.
[14] RASIC I,RASIC A,AKSAMIJA G,et al.The relationship between serum level of malondialdehyde and progression of colorectal cancer[J].Acta Clin Croat,2018,57(3):411-416.
[15] ABD E L,NABY S A,NAGUIB Y M.Sociodemographic,electrophysiological,and biochemical profiles in children with attention deficit hyperactivity disorder and/or epilepsy[J].Behav Neurol,2018,2018:8932817.
[16] FERREIRA A G K,BIASIBETTI-BRENDLER H,SIDEGUM D S V,et al.Effect of proline on cell death,cell cycle,and oxidative stress in C6 glioma cell line[J].Neurotox Res,2021,39(2):327-334. |