Objective: To investigate the relationship between the expression of vascular endothelial growth factor receptor-2(VEGFR-2) and disease recurrence and prognosis in meningiomas. Methods: 143 patients with meningioma treated in our hospital from August 2016 to August 2018 were selected as meningioma group, and 69 patients with brain tissue removed due to brain trauma in the same period were selected as control group. The expression of VEGFR-2 in the two groups was compared and followed up for 3 years. According to the prognosis, they were divided into good prognosis group and poor prognosis group, multivariate Cox regression model was used to analyze the prognostic risk factors of meningiomas. Kaplan-Meier survival curve and Log-rank χ2 test were used to analyze the relationship between VEGFR-2 expression and recurrence rate, and cumulative survival rate was analyzed. Results: The positive rate of VEGFR-2 in the meningioma group was 78.32%, which was higher than 14.49% in the control group(P<0.05). The poor prognosis group had more cases with age ≥ 50 years old, the maximum tumor diameter ≥ 5 cm, vascular nerve, cavernous sinus involvement, optic canal involvement, VEGFR-2 positive and WHO grade Ⅲ than those in the good prognosis group, and had lower proportions of total resection and postoperative adjuvant therapy than those in the good prognosis group(P<0.05). Multiple Cox regression model analysis showed that the maximum tumor diameter ≥ 5 cm, surrounding blood vessels and nerves, involvement of cavernous sinus, positive VEGFR-2 and WHO grade Ⅲ were the risk factors for poor prognosis of meningiomas, and total resection and postoperative adjuvant treatment were the protective factors for prognosis(P<0.05). The recurrence rate of VEGFR-2 positive group was higher than that of VEGFR-2 negative group(P<0.05). Conclusion: The positive expression of VEGFR-2 is increased in meningiomas, and the 3-year disease recurrence rate was higher in those with positive expression, however, it has no significant effect on the cumulative survival rate. |
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