Objective: To study on the relationship between serum C-X-C motif chemokine ligand 10(CXCL10) levels and the severity and prognosis of community acquired pneumonia(CAP). Methods: A total of 180 patients with CAP received in our hospital from October 2018 to June 2022 were selected as an experimental group(CAP group). In addition, 100 health examinees in the same period were included in a control group. Serum CXCL10 level was detected by ELISA, and the relationship between CXCL10 level and the severity and prognosis of CAP was analyzed; the correlation analysis of serum CXCL10 level with laboratory indexes and CAP severity score was performed by Pearson method; the influencing factors of the prognosis of CAP patients were analyzed by logistic regression. ROC curve was used to analyze the predictive value of serum CXCL10 level for the severity and prognosis of patients with CAP. Results: Compared with the control group, the leukocytes, neutrophils, NLR, MON, PLR, IL-6, IL-1, TNF, CRP, CXCL10 were obviously increased in the CAP group, while lymphocytes and uric acid were obviously decreased(P<0.05). With the increase of the severity of CAP disease, CXCL10 in PSI, CURB-65, CRB-65, SMART-COP and CURXO increased gradually(P<0.05). The CXCL10 level in the serum of CAP patients was positively correlated with PLR, IL-1, TNF, PSI, CURB-65, SMART-COP, CURXO(r=0.550, 0.573, 0.593, 0.649, 0.663, 0.658, 0.514, 0.579, all P<0.05). ROC results showed that the AUC of serum CXCL10 level in predicting the severity and poor prognosis of CAP patients was 0.835 and 0.816, respectively. Conclusion: The level of CXCL10 in serum of patients with CAP increases. With the increase of the severity of CAP disease, the severity score of CAP disease gradually increases. The serum CXCL10 has a certain predictive value for the severity and prognosis of CAP disease. |
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