血清AMH、INHB联合经阴道彩超对IVF-ET助孕患者助孕成功的预测价值-东南大学学报医学版

血清AMH、INHB联合经阴道彩超对IVF-ET助孕患者助孕成功的预测价值

单位：1. 河北省沧州中西医结合医院超声科, 河北沧州 061000;
2. 河北省沧州中西医结合医院生殖医学科, 河北沧州 061000;
3. 河北省沧州中西医结合医院超声一科, 河北沧州 061000;
4. 河北省沧州中西医结合医院体检科, 河北沧州 061000

关键词：抗苗勒氏管激素抑制素B 阴道彩色超声体外受精-胚胎移植助孕

分类号：R714.8

出版年·卷·期（页码）：2024·43·第五期（711-716）

摘要：

目的: 探讨体外受精-胚胎移植(IVF-ET)助孕患者血清中抗苗勒氏管激素(AMH)、抑制素B(INHB)联合经阴道彩超预测患者助孕成功的价值。方法: 收集本院2019年1月至2023年1月期间进行IVF-ET助孕的160例患者作为研究对象,根据是否助孕成功将其分为未妊娠组(n=86)和妊娠组(n=74)。比较两组血清AMH、INHB水平和阴道彩超结果;ROC曲线分析血清AMH、INHB联合经阴道彩超对IVF-ET助孕患者助孕成功的预测价值;多因素Logistic回归分析IVF-ET助孕患者助孕成功的影响因素。结果: 与妊娠组相比,未妊娠组获卵数、AMH、INHB显著降低(P<0.05)。阴道彩超检查结果显示,未妊娠组子宫内膜厚度显著厚于妊娠组(P<0.05)。ROC曲线显示,AMH、INHB、阴道彩超三者联合预测IVF-ET助孕患者助孕成功的AUC为0.956,敏感性为95.35%,特异性为83.78%,优于AMH、INHB、阴道彩超各自单独预测(Z_联合检测_-AMH=4.543,Z_联合检测_-INHB=3.733,Z_{联合检测-子宫内膜厚度}=4.511,均P＜0.001)。多因素Logistic回归分析结果显示,获卵数、AMH、INHB、子宫内膜厚度是IVF-ET助孕患者助孕成功的影响因素(P<0.05)。结论: 血清AMH、INHB联合经阴道彩超对IVF-ET助孕患者是否成功妊娠具有一定的预测价值。

Objective: To explore the value of serum anti Mullerian hormone(AMH) and inhibin B(INHB) combined with transvaginal ultrasound in predicting pregnancy outcomes in patients undergoing in vitro fertilization and embryo transfer(IVF-ET) assisted pregnancy. Methods: A total of 160 patients who underwent IVF-ET assisted pregnancy in our hospital from January 2019 to January 2023 were regarded as research subjects. They were separated into non pregnant group(n=86) and pregnant group(n=74) based on pregnancy outcomes. The serum AMH, INHB levels, and vaginal ultrasound results of the two groups were compared; ROC curve was applied to analyze the predictive value of serum AMH, INHB combined with transvaginal ultrasound for pregnancy outcomes in IVF-ET assisted patients; Multivariate Logistic regression was used to analyze the influencing factors of pregnancy outcomes in patients undergoing IVF-ET. Results: Compared with the pregnant group, the number of oocytes retrieved, AMH and INHB levels in the non pregnant group were significantly reduced(P<0.05). The results of vaginal ultrasound examination showed that the thickness of endometrium in the non pregnant group was significantly higher than that in the pregnant group(P<0.05). ROC curve showed that the AUC of AMH, INHB combined with vaginal ultrasound to predict the pregnancy outcome of IVF-ET assisted pregnancy patients was 0.956, with a sensitivity of 95.35% and a specificity of 83.78%, which was better than AMH, INHB, and vaginal ultrasound alone(Z_{combined detection-AMH}=4.543, Z_{combined detection-INHB}=3.733, Z_{combined detection-endometrial thickness}=4.511,all P＜0.001). Multivariate Logistic regression analysis showed that the number of oocytes retrieved, AMH, INHB levels and endometrial thickness were the influencing factors of pregnancy outcomes in patients with IVF-ET. Conclusion: Serum AMH, INHB combined with transvaginal ultrasound has certain predictive value for IVF-ET assisted pregnancy patients.

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