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HMGB1激活NF-κB信号通路介导的免疫反应在DQ中毒导致肾脏损伤中作用的研究进展
作者:任红林1  吴瑾1  潘俊伟1  廖娅1  张小军1  夏彩云1  胡杰2  陆元兰1 3 
单位:1. 遵义医科大学附属医院 急诊科, 贵州 遵义 563000;
2. 遵义医科大学附属医院 重症医学科, 贵州 遵义 563000;
3. 遵义医科大学附属医院 门诊部, 贵州 遵义 563000
关键词:高迁移率族蛋白B1 转录因子-κB 免疫平衡 敌草快 综述 
分类号:R459.7
出版年·卷·期(页码):2024·43·第五期(806-810)
摘要:

急性肾损伤(AKI)是敌草快(DQ)中毒的早期并发症,及早干预AKI可改善患者预后及生存率。但DQ诱导AKI的发病机制复杂,现有研究发现脾脏中免疫平衡紊乱在AKI的发病机制中起重要作用。高迁移率族蛋白B1(HMGB1)与Toll样受体(TLR)、晚期糖基化终末产物受体(RAGE)相互作用,激活转录因子-κB(NF-κB)信号通路启动下游炎症因子、打破免疫平衡在组织损伤的机制中具有重要作用。本综述通过探讨HMGB1的表达在DQ诱导AKI中的具体作用,发现除氧化应激及炎症反应外,免疫紊乱也参与了DQ中毒导致组织损伤的机制,为DQ中毒的治疗提供新方向。

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