最大通气-支气管激发听诊试验对咳嗽变异型哮喘的诊断价值-东南大学学报医学版

最大通气-支气管激发听诊试验对咳嗽变异型哮喘的诊断价值

单位：东南大学附属中大医院呼吸与危重医学科, 江苏南京 210009

分类号：R562.25

出版年·卷·期（页码）：2025·44·第一期（13-17）

摘要：

目的:探讨最大通气-支气管激发听诊试验(MVV-BP-AT)检测气道反应性及其对咳嗽变异型哮喘(CVA)的诊断价值。方法:对疑似CVA患者首先进行MVV-BP-AT检查,阳性者为MVV组。然后行用力肺功能检查和支气管舒张试验(BDT),按FEV1标准舒张试验阳性患者为BDT组。BDT阳性的患者确诊CVA,归于CVA组;对BDT阴性的患者3 d后再行支气管激发试验(BPT),阳性者诊断CVA,归于CVA组。比较MVV-BP-AT和BDT对CVA的诊断效能。结果:BDT和MVV-BP-AT对CVA诊断的敏感度分别为32.7%和83.7%,特异度均为100%。MVV-BP-AT对CVA诊断的敏感度明显高于BDT。结论:MVV-BP-AT可以作为一种支气管激发试验,用于临床CVA的诊断,其简单、方便、安全,便于临床应用。

Objective: To investigate the maximal voluntary ventilation bronchial provocative auscultation test(MVV-BP-AT) for detecting airway reactivity and its diagnostic value for cough variant asthma(CVA). Methods: Patients with suspected CVA were firstly subjected to MVV-BP-AT, and those who were positive were in MVV group. Then, exertion pulmonary function test and bronchodilator test(BDT) were performed, and patients with positive diastolic test according to FEV1 criteria were allocated into BDT group. The diagnosis of CVA was confirmed in patients positive in bronchodilator test and those negative in bronchodilator test but positive in bronchial provocation test(BPT) performed 3 days later. The diagnostic efficacy of MVV-BP-AT and BDT for CVA was compared. Results: The sensitivity of BDT and MVV-BP-AT for the diagnosis of CVA was 32.7% and 83.7%, respectively, and the specificity was 100%. The sensitivity of MVV-BP-AT for the diagnosis of CVA was significantly higher than that of BDT. Conclusion: MVV-BP-AT can be used as bronchial stimulation test for the diagnosis of clinical CVA in clinic, which is simple, safe and convenient to be applied in clinical. It is simple, safe and convenient for clinical application.

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