HPA3基因多态性与突发性耳聋患者病情转归不良的关系研究-东南大学学报医学版

HPA3基因多态性与突发性耳聋患者病情转归不良的关系研究

单位：空军军医大学第一附属医院耳鼻喉科, 陕西西安 710032

分类号：R764.437

出版年·卷·期（页码）：2025·44·第六期（940-945）

摘要：

目的: 探讨人类血小板抗原3(HPA3)基因多态性与突发性耳聋患者病情转归不良的关系。方法: 选取147例突发性耳聋患者作为研究对象,均进行HPA3基因型检测。根据患者治疗2周后的病情转归情况将突发性耳聋患者分为转归不良组和转归良好组,比较两组HPA3基因多态性,并分析其与突发性耳聋患者病情转归不良的关系。结果: 两组听力损失程度、听力曲线类型、血浆黏度、全血高切黏度、全血低切黏度比较差异有统计学意义(P＜0.05)。转归不良组HPA3基因aa基因型和等位基因a的频率更高(P＜0.05),等位基因b的频率更低(P＜0.05)。重度听力损失、全频下降型听力曲线、血浆黏度≥2 mPa·s、HPA3基因aa基因型和等位基因a均为突发性耳聋患者病情转归不良的危险因素(P＜0.05)。结论: HPA3基因aa基因型和等位基因a与突发性耳聋患者病情转归不良有关。

Objective: To explore the relationship between human platelet antigen 3(HPA3) gene polymorphism and poor prognosis in patients with sudden deafness. Methods: 147 patients with sudden deafness were selected as the study subjects, and they all underwent HPA3 genotype test. Patients with sudden deafness were divided into poor outcome group and good outcome group based on the outcome of the patient's condition after 2 weeks of treatment. The HPA3 gene polymorphism between the two group was compared, and the relationship between it and poor prognosis in patients with sudden deafness was analyzed. Results: There were statistical differences in the degree of hearing loss, types of hearing curve, plasma viscosity, high shear blood viscosity and low shear blood viscosity between the two groups(P<0.05). The frequency of aa genotype and a allele of HPA3 gene in poor outcome group were higher, while the frequency of b allele was lower(P<0.05). The severe hearing loss, full frequency descending hearing curve, plasma viscosity ≥2 mPa·s, aa genotype and a allele of HPA3 gene were risk factors for poor prognosis in patients with sudden deafness(P<0.05). Conclusion: The aa genotype and a allele of HPA3 gene are associated with poor prognosis in patients with sudden deafness.

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