Objective: To explore the influencing factors of intrauterine adhesion in cervical intraepithelial neoplasia(CIN) grade Ⅱ-Ⅲ patients with high-risk human papillomavirus(HPV) infection after loop electrical excision procedure(LEEP), and construct a quantitative risk prediction model. Methods: The clinical data of 588 high-risk HPV infected CIN Ⅱ-Ⅲ patients treated with LEEP in our hospital from May 2022 to May 2025 were retrospectively analyzed, and they were randomly divided into an observation group(n=392) and a validation group(n=196) in a 2:1 ratio. The occurrence of postoperative intrauterine adhesion in patients was counted, and the observation group patients were divided into adhesion group and non adhesion group based on this, and the clinical data of the two groups was compared. The influencing factors of intrauterine adhesion in high-risk HPV infected CIN Ⅱ-Ⅲ patients after LEEP surgery was screened using multiple Logistic regression analysis, and a risk prediction column chart model was constructed and validated. Results: 65 cases in the observation group experienced intrauterine adhesions. The proportions of cesarean section history, curettage history, intrauterine device placement history and CIN grade Ⅲ in the adhesion group were all higher than those in the non adhesion group(P<0.05), and HPV load, resection depth were all greater than those in the non adhesion group(P<0.05), and the proportion of postoperative probiotic use was lower than that in the non adhesion group(P<0.05). Through multiple Logistic regression analysis, the cesarean section history, curettage history, intrauterine device placement history, CIN grade Ⅲ and resection depth were all risk factors for intrauterine adhesion after LEEP in high-risk HPV infected CIN Ⅱ-Ⅲ patients(P<0.05), while the use of probiotics after surgery was a protective factor(P<0.05). Based on the above influencing factors, a quantitative column chart model for predicting the risk of intrauterine adhesion in high-risk HPV infected CIN Ⅱ-Ⅲ patients after LEEP surgery was constructed. Calibration curve evaluation showed that the calibration curves of the observation group and validation group were close to the ideal curve. The ROC curve evaluation showed that the area under the curve for predicting the risk of intrauterine adhesion after LEEP in the observation group and validation group patients was 0.875 and 0.870 respectively. The DCA curve evaluation showed that when the threshold probabilities of the observation group was 0.13-0.55 and 0.59-0.74, and when the threshold probabilities of the validation group were 0.10-0.79 respectively, using this model to evaluate the risk of postoperative intrauterine adhesion had a significant clinical net benefit. Conclusion: The cesarean section history, curettage history, intrauterine device placement history, CIN grade Ⅲ, resection depth and probiotic use are all influencing factors for the occurrence of intrauterine adhesion in high-risk HPV infected CIN Ⅱ-Ⅲ patients after LEEP surgery. Based on this, a risk prediction quantitative column chart model can effectively predict the risk of intrauterine adhesion in such patients after surgery, which can help guide early screening of high-risk patients in clinical practice and develop corresponding personalized intervention measures.