胃癌中Maspin与iNOS的相互关系及临床病理意义-东南大学学报医学版

胃癌中Maspin与iNOS的相互关系及临床病理意义

作者：王鹏

单位：辽宁医学院附属一院

关键词：Maspin(Mammary-serpin) iNOS(nitric oxide synthase iNOS) 胃癌免疫组织化学

分类号：

出版年·卷·期（页码）：2010·29·第六期（635-638）

摘要：

摘要目的：研究Maspin与iNOS在胃癌中表达的相互关系，探讨它们在胃癌的发生发展、浸润和转移中的作用。方法：应用免疫组化SP法检测54例胃癌中Maspin、iNOS的表达情况,探讨Maspin、iNOS与胃癌临床病理因素的关系。结果：胃癌中Maspin低表达（12/54，22.2%），且有淋巴转移（P <0.05）、临床分期高（P <0.05）、病理分化低（P <0.05）时降低。iNOS在胃癌中的表达率（74.07％）明显高于正常胃组织（0%），P <0.01; iNOS的表达与胃癌TNM分期、肿瘤浸润深度和淋巴结转移显著相关，P <0.05。胃癌组织中Maspin与iNOS的表达呈负相关(r = -0.45, P<0.05)。结论： Maspin和iNOS在胃癌的发生发展中起重要作用，联合检测可作为判断胃癌恶性程度和预后的指标。

Abstract Objective: To study the expression of Maspin and iNOS in gastric cancer and their relationship with tumor angiogenesis,clinicopathologic feature and prognosis. Methods: Immunohistochemical technique was used to detect the expression of Maspin and iNOS in 54 cases of gastric cancer.The relationship between the expression of Maspin, iNOS and tumor angiogenesis,clinicopathologic feature of patients was analyzed. Results: The expression of Maspin in gastric cancers was low (12/54, 22.2%), and reduced with increased clinical stages (P <0.05), reduced histological differentiation ( P <0.05) and occurring of lymphatic metastasis (P <0.05); The positive expression rate of iNOS in gastric cancer(74.07％) was significantly higher than that in normal gastric tissue (0%)， P <0.01; The expression of iNOS in gastric cancer was significantly associated with TNM stage, invasive depth and lymph-node metastasis, P < 0.05. There was a negative correlation between expression of Maspin and iNOS (r = -0.45, P<0.05). Conclusion: Maspin and iNOS play the very important role in the development in gastric cancer , could be a factor in diagnosis of gastric cancer and estimation of prognosis.

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